Publications
Peer-Reviewed Publications:
Endothelial Cell APOE3 Regulates Neurovascular, Neuronal, and Behavioral Function. Marottoli FM, Zhang H, Flores-Barrera E, Artur de Villarmois E, Damen FC, Miguelez Fernández AMM, Blesson HV, Chaudhary R, Nguyen AL, Nwokeji AE, Talati R, John AS, Madadakere K, Lutz SE, Cai K, Tseng KY, Tai LM. Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):1952-1966. PMID: 37650329
LPC-DHA/EPA-enriched diets increase brain DHA and modulate behavior in mice that express human APOE4. Scheinman SB, Zayed M, Yalagala PCR, Sugasini D, Subbaiah PV, Tai LM. Front Neurosci. 2021 Jul 1:15:690410. PMID: 34276296
Autocrine effects of brain endothelial cell-produced human apolipoprotein E on metabolism and inflammation in vitro. Marottoli FM, Trevino TN, Geng X, Arbieva Z, Kanabar P, Maienschein-Cline M, Lee JC, Lutz SE, Tai LM. Front Cell Dev Biol. 2021 Jun 10;9:668296. PMID: 34178992
APOE4 promotes tonic-clonic seizures, an effect modified by familial Alzheimer's disease mutations. Lamoureux L, Marottoli FM, Tseng KY, Tai LM. Front Cell Dev Biol. 2021 Mar 16;9:656521. PMID: 33796539
Systemic candesartan treatment modulates behavior, synaptic protein levels, and neuroinflammation in female mice that express human APOE4. Scheinman SB, Zaldua S, Dada A, Krochmaliuk K, Dye K, Marottoli FM, Thatcher GRJ, Tai LM. Front Neurosci. 2021 Feb 10;15:628403. PMID: 33642985
Relevance of transgenic mouse models for Alzheimer's disease. Tai LM, Maldonado Weng J, LaDu MJ, Brady ST. Prog Mol Biol Transl Sci. 2021;177:1-48. PMID: 33453936
Epidermal growth factor treatment of female mice that express APOE4 mitigates cognitive and cerebrovascular dysfunction in a reversal paradigm. Zaldua S, Damen FC, Pisharody R, Thomas R, Fan KD, Ekkurthi GK, Scheinman SB, Marottoli FM, Alford S, Cai K, Tai LM. Heliyon. 2020 May 25;6(5):e03919. PMID: 32478184
EGF treatment improves motor behavior and cortical GABAergic function in the R6/2 mouse model of Huntington’s disease. Marottoli FM, Priego M, Flores-Barrera E, Pisharody R, Zaldua S, Fan KD, Ekkurthi GK, Brady ST, Morfini GA, Tseng KY, Tai LM. Mol Neurobiol. 2019 Nov;56(11):7708-7718. PMID: 31104296
EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease. Tai LM, Balu D, Avila-Munoz E, Abdullah L, Thomas R, Collins N, Valencia-Olvera AC, Ladu MJ. J Lipid Res. 2017 Sep;58(9):1733-1755. PMID: 28389477
Peripheral Inflammation, Apolipoprotein E4, and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction. Marottoli FM, Katsumata Y, Koster KP, Thomas R, Fardo DW, Tai LM. ASN Neuro. 2017 Jul-Aug;9(4):1759091417719201. PMID: 28707482
In Vitro Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption. Thomas R, Diaz K, Koster KP, Tai LM. J Vis Exp. 2017 Jun 20;(124). PMID: 28626809
Epidermal growth factor prevents APOE-induced cognitive and cerebrovascular deficits in female mice. Thomas R, Morris AWJ, Tai LM. Heliyon. 2017 Jun 7;3(6):e00319. PMID: 28626809
EFAD Transgenic Mice as a Human APOE Relevant Preclinical Model of Alzheimer's Disease. Tai LM, Balu D, Avila-Munoz E, Abdullah L, Thomas R, Collins N, Valencia-Olvera AC, LaDu MJ. J Lipid Res. 2017 Apr 7. PMID: 28389477
Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits in vitro. Koster KP, Thomas R, Morris AW, Tai LM. J Cereb Blood Flow Metab. 2016 Nov;36(11):1865-1871. PMID: 27634936
Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice. Thomas R, Zuchowska P, Morris AW, Marottoli FM, Sunny S, Deaton R, Gann PH, Tai LM. Acta Neuropathol Commun. 2016 Oct 27;4(1):111. PMID: 27788676
The role of APOE in cerebrovascular dysfunction. Tai LM, Thomas R, Marottoli FM, Koster KP, Kanekiyo T, Morris AW, Bu G. Acta Neuropathol. 2016 May;131(5):709-23. Review. PMID: 26884068
Collaborations & Previous Work:
Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease. Heller GJ, Marshall MS, Issa Y, Marshall JN, Nguyen D, Rue E, Pathmasiri KC, Domowicz MS, van Breemen RB, Tai LM, Cologna SM, Crocker SJ, Givogri MI, Sands MS, Bongarzone ER. Mol Ther. 2021 May 5;29(5):1883-1902. PMID: 33508430
Extending the calpain-cathepsin hypothesis to the neurovasculature: protection of brain endothelial cells and mice from neurotrauma. Knopp RC, Jastaniah A, Dubrovskyi O, Gaisina I, Tai L, Thatcher GRJ. ACS Pharmacol Transl Sci. 2021 Feb 2;4(1):372-385. PMID: 33615187
Lipase treatment of dietary krill oil, but not fish oil, enables enrichment of brain eicosapentaenoic acid and docosahexaenoic acid. Yalagala PCR, Sugasini D, Zaldua SB, Tai LM, Subbaiah PV. Mol Nutr Food Res. 2020 Jun;64(12):e2000059. PMID: 32304625
Murine gut microbiome association with APOE alleles. Parikh IJ, Estus JL, Zajac DJ, Malik M, Maldonado Weng J, Tai LM, Chlipala GE, LaDu MJ, Green SJ, Estus S. Front Immunol. 2020 Feb 14;11:200. PMID: 32117315
Exercise training results in lower amyloid plaque load and greater cognitive function in an intensity dependent manner in the Tg2576 mouse model of Alzheimer's disease. Thomas R, Zimmerman SD, Yuede KM, Cirrito JR, Tai LM, Timson BF, Yuede CM. Brain Sci. 2020 Feb 8;10(2):88. PMID: 32046299
Evaluation of B0-correction of relative CBF maps using tagging distance dependent Z-spectrum (TADDZ). Damen FC, Tain RW, Thomas R, Li W, Tai L, Cai K. Magn Reson Imaging. 2020 Jan;65:83-89. PMID: 31669538
Enrichment of brain docosahexaenoic acid (DHA) is highly dependent upon the molecular carrier of dietary DHA: Lysophosphatidylcholine is more efficient than either phosphatidylcholine or triacylglycerol. Dhavamani S, Yalagala P, Goggin A, Tai LM, Subbaiah P. J Nutr Biochem. 2019 Aug 31;74:108231. PMID: 31665653
Depletion of Caveolin-1 in Type 2 Diabetes Model Induces Alzheimer's Disease Pathology Precursors. Bonds JA, Shetti A, Bheri A, Chen Z, Disouky A, Tai L, Mao M, Head BP, Bonini MG, Haus JM, Minshall RD, Lazarov O. J Neurosci. 2019 Oct 23;39(43):8576-8583. PMID: 31527120
N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability. Kruse K, Lee QS, Sun Y, Klomp J, Yang X, Huang F, Sun MY, Zhao S, Hong Z, Vogel SM, Shin JW, Leckband DE, Tai LM, Malik AB, Komarova YA. J Cell Biol. 2019 Jan 7;218(1):299-316. PMID: 30463880
Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice. Sugasini D, Thomas R, Yalagala PCR, Tai LM, Subbaiah PV. Sci Rep. 2017 Sep 12;7(1):11263. PMID: 28900242
APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease. Abdullah L, Evans JE, Emmerich T, Crynen G, Shackleton B, Keegan AP, Luis C, Tai L, LaDu MJ, Mullan M, Crawford F, Bachmeier C. Aging. 2017; 9(3):964-985. PMID: 28333036
Rexinoids as Therapeutics for Alzheimer's Disease: Role of APOE. Koster KP, Smith C, Valencia-Olvera AC, Thatcher GR, Tai LM, LaDu MJ. Curr Top Med Chem. 2017;17(6):708-720. Review. PMID: 27320328
Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer's disease in vitro. Ghura S, Tai L, Zhao M, Collins N, Che CT, Warpeha KM, LaDu MJ. Scientific reports. 2016; 6:29364. PMID: 27383500
A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. Molecular neurodegeneration. 2016; 11:35. PMID: 27129593
Genetics ignite focus on microglial inflammation in Alzheimer's disease. Malik M, Parikh I, Vasquez JB, Smith C, Tai L, Bu G, LaDu MJ, Fardo DW, Rebeck GW, Estus S. Molecular neurodegeneration. 2015; 10:52. PMID: 26438529
APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Liu DS, Pan XD, Zhang J, Shen H, Collins NC, Cole AM, Koster KP, Ben Aissa M, Dai XM, Zhou M, Tai LM, Zhu YG, LaDu M, Chen XC. Mol Neurodegener. 2015 Mar 5;10:7. PMID: 25871877
Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. Tai LM, Koster KP, Luo J, Lee SH, Wang YT, Collins NC, Ben Aissa M, Thatcher GR, LaDu MJ. J Biol Chem. 2014 Oct 31;289(44):30538-55. PMID: 25217640
White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults. Gold BT, Zhu Z, Brown CA, Andersen AH, LaDu MJ, Tai L, Jicha GA, Kryscio RJ, Estus S, Nelson PT, Scheff SW, Abner E, Schmitt FA, Van Eldik LJ, Smith CD. Neurobiology of aging. 2014; 35(10):2263-71. PMID: 24866404
Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition. Rodriguez GA, Tai LM, LaDu MJ, Rebeck GW. J Neuroinflammation. 2014 Jun 19;11:111. PMID: 24948358
APOE modulates the effect of estrogen therapy on Aβ accumulation EFAD-Tg mice. Kunzler J, Youmans KL, Yu C, Ladu MJ, Tai LM. Neurosci Lett. 2014 Feb 7;560:131-6. PMID: 24368217
Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Tai LM, Mehra S, Shete V, Estus S, Rebeck GW, Bu G, LaDu MJ. Mol Neurodegener. 2014 Jan 4;9:2. doi: 10.1186/1750-1326-9-2. Review. PMID: 24386905
Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, Ladu MJ. J Biol Chem. 2013 Feb 22;288(8):5914-26. PMID: 23293020
APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, Ladu MJ. J Biol Chem. 2012 Dec 7;287(50):41774-86. PMID: 23060451
The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat. Tai LM, Jacobsen H, Ozmen L, Flohr A, Jakob-Roetne R, Caruso A, Grimm HP. J Pharmacokinet Pharmacodyn. 2012 Jun;39(3):227-37. PMID: 22481485
APOE genotype alters glial activation and loss of synaptic markers in mice. Zhu Y, Nwabuisi-Heath E, Dumanis SB, Tai LM, Yu C, Rebeck GW, LaDu MJ. Glia. 2012 Apr;60(4):559-69. PMID: 22228589
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody. Youmans KL, Tai LM, Kanekiyo T, Stine WB Jr, Michon SC, Nwabuisi-Heath E, Manelli AM, Fu Y, Riordan S, Eimer WA, Binder L, Bu G, Yu C, Hartley DM, LaDu MJ. Mol Neurodegener. 2012 Mar 16;7:8. PMID: 22423893
Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift. LaDu MJ, Munson GW, Jungbauer L, Getz GS, Reardon CA, Tai LM, Yu C. Biochim Biophys Acta. 2012 Feb;1821(2):295-302. PMID: 22138302
Introducing Human APOE into Aβ Transgenic Mouse Models. Tai LM, Youmans KL, Jungbauer L, Yu C, Ladu MJ. Int J Alzheimers Dis. 2011;2011:810981. PMID: 22028984
Amyloid-beta-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation. Tai LM, Holloway KA, Male DK, Loughlin AJ, Romero IA. J Cell Mol Med. 2010 May;14(5):1101-12. PMID: 19438816
Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123. Tai LM, Reddy PS, Lopez-Ramirez MA, Davies HA, Male DK, Loughlin AJ, Romero IA. Brain Res. 2009 Oct 6;1292:14-24. Erratum in: Brain Res. 2010 Jan 8;1306:184. Male, A David K [corrected to Male, David K]. PMID: 19631619
P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta. Tai LM, Loughlin AJ, Male DK, Romero IA. J Cereb Blood Flow Metab. 2009 Jun;29(6):1079-83. PMID: 19367293
Book Chapters:
Basic Neurochemistry 8th ed. USA: Elsevier; 2011. Chapter Chapter 1 , Cell Biology of the Nervous System